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Dr Nicky Simler is the Clinical Lead for the Cambridge Interstitial Lung Disease Unit. She graduated from Manchester Medical School in 1993. Dr Simler completed an MD Thesis whilst working in the Interstitial Lung Disease service at Wythenshawe Hospital investigating the role of pro-angiogenic cytokines in interstitial pneumonia.

She completed her higher respiratory training in North West Thames with experience in the Royal Brompton Interstitial Lung Disease service before taking up her consultant role in Hinchingbrooke and Royal Papworth Hospitals in 2006.

Dr Simler has an interest in Clinical Trials and is currently the Respiratory Specialty Lead for the Eastern Clinical Research Network.  She is also the Training Programme Director for Respiratory Medicine in the East of England.

Specialist Clinical Interests

Interstitial Lung Disease

Research Interests

Clinical trials

Education and Training
  • Manchester University School of Medicine MBChB 1993
  • Manchester University School of Medicine MD 2003
  • CCST Respiratory and General Medicine 2006, North West Thames Training Rotation
  • Royal College of Physicians, London FRCP 2010
Current membership(s) of professional, national and regional bodies and university posts
  • Fellow of the Royal College of Physicians, London 2010
  • Member of the General Medical Council (registration number: 4023410).
  • Member of the British Thoracic Society and European Respiratory Society
  • Respiratory Specialty Lead for Clinical Research Network Eastern since Sept 2014
  • Training Programme Director for Respiratory Medicine, Health Education East of England, since Aug 2018
Recent and Important Publications

NR Simler, DCJ Howell, RP Marshall, NR Goldsack, PS Hasleton, GJ Laurent, RC Chambers, JJ Egan. The rapamycin analogue Sdz Rad attenuates bleomycin-induced pulmonary fibrosis in rats. Eur Respir J 2002; 19:1124-1127

NR Simler, PEC Brenchley, AW Horrocks, MS Greaves, PS Hasleton, JJ Egan. Angiogenic cytokines in patients with idiopathic interstitial pneumonia. Thorax 2004; 59(7):581-585

MI Saleem, PBrenchley, NR Simler, JJ Egan. VEGF in idiopathic ILD. Thorax 2005; 60(4):353-4

Watson P, Simler N, Screaton N, Lillicrap M. Management of accelerated pulmonary nodulosis following etanercept therapy in a patient with rheumatoid arthritis. Rheumatology 2008 Jun;47(6):928-9

C Harris,L Sharkey,G Koshy, N Simler, JA Karas. A rare case of acute epiglottitis due to Staphylococcus aureus in an adult. Infect Dis Rep 2012 Jan;4(1):e3

C Fiddler, N Simler, H Parfrey, A Miremadi, E R Chilvers.Severe Colitis Associated with Pirfenidone use in Idiopathic Pulmonary Fibrosis. Annals of the American Thoracic Society 2016 Aug 13(8) 1430-2.

S Fletcher, M Jones, E Renzoni, H Parfrey , R Hoyles, K Spinks, M Kokosi, A Kwok, C Warburton, V Titmuss, M Thillai, NR Simler, T Maher, C Brereton, F Chua, A Wells, L Richeldi and L Spencer. Safety and tolerability of Nintedanib for the treatment of idiopathic pulmonary fibrosis in routine UK clinical practice. ERJ Open Research 2018 19;4(4)

Contact details:

SwitchBoard: 01223 638000

Secretary

Dorrie Clarke

Telephone: 01223 638786

Email: dorrie.clarke@nhs.net

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