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Heart research

Cardiology: Interventional, Medicinal, Observational
  • CAIS: Cardiovascular Acoustics and an Intelligent Stethoscope.  An observational study to collect heart sound recordings from patients to understand the acoustic characteristics of murmurs and develop an artificially intelligent stethoscope.  CI Dr B Rana Sponsor: Papworth Hospital NHS Foundation Trust and Cambridge University.
  • EMPIRE BVS: Evaluation of microcirculatory protection during percutaneous coronary intervention with bioresorbable vascular scaffolds versus metallic drug-eluting stents: a device and implant technique based comparison. Study summary here;CI Dr S Hoole Sponsor: Papworth Hospital NHS Foundation Trust 
  • DREAM GLP Diastolic RV EvAluation With Millar Catheter to Investigate the Effect of Glucagon-Like Peptide-1 (GLP-1) on Right Ventricular Function During Elective Coronary Angioplasty and Stenting. Click here for further information. CI Dr S Hoole Sponsor: Papworth Hospital NHS Foundation Trust
  • RITA MI Dose Effect Relationship of a Single Dose of Rituximab on the Kinetics of B Lymphocytes in Patients with Acute STSegment Myocardial Infarction. For further information click here.  CI Dr S Hoole Sponsor: Papworth Hospital NHS Foundation Trust
  • TIMES: A Randomised Mechanistic Study Comparing the Effects of Different Anti-platelet Combinations (Ticagrelor vs. Placebo/ Clopidogrel) with Aspirin in Patients presenting with Anterior STEMI Treated with Primary PCI Further Information HERE; CI Dr S Hoole Sponsor: Papworth Hospital NHS Foundation Trust 
  • The Effect of Glucagon-Like Peptide-1 (GLP-1) on Pulmonary Vascular Resistance (PVR) in Patients With Heart Failure. Click here for further information. CI: Dr Jayan Parameshwar; Sponsor: Papworth Hospital NHS Foundation Trust                                                           
  • CRAFT: Cryoballoon Pulmonary Vein Isolation as First Line Treatment for Typical Atrial Flutter. PI Dr C Martin. Sponsor: Liverpool Heart and Chest Hospital https://clinicaltrials.gov/ct2/show/NCT03401099
  • COHORT substudy: Minimally-invasive phenotyping of arrhythmias in idiopathic pulmonary arterial hypertension. A sub-study of the National Cohort study of Idiopathic and Heritable Pulmonary Arterial Hypertension. PI Dr C Martin and Dr M Toshner. Sponsor: Royal Papworth Hospital NHS Foundation Trust http://www.ipahcohort.com/
  • PRAETORIAN-DFT: A Prospective Randomised Comparative trial of Subcutaneous Implantable Cardioverter-Defibrillator Implantation with and without Defibrillation Testing. CI Dr C Martin. Sponsor: Academic Medical Center, Amsterdam, the Netherlands https://clinicaltrials.gov/ct2/show/NCT03495297
  • INTERRUPT-AF: Prospective Evaluation of Open Irrigated Ablation Catheters With High Resolution Mapping to Treat Paroxysmal Atrial Fibrillation. CI Dr C Martin. Sponsor: Boston Scientific https://clinicaltrials.gov/ct2/show/NCT03729830

Lung research

Surgery / Transplant
Lung Cancers
  • TIDAL: Feasibility Study to Estimate Number of Patients With Precancerous Areas in Their Airways and the Response to Gefitinib (TIDAL1), Sponsor: Papworth Hospital NHS Foundation Trust

CI Prof T Eisen Click here for further information and Here

  • Approaches to earlier detection & intervention in lung cancer-Study 1a. UKCRN ID 14157
  • MESOTRAP: A feasibility study comparing video-assisted thoracoscopic partial pleurectomy/decortication with indwelling pleural catheter in patients with trapped lung due to malignant pleural mesothelioma designed to address recruitment and randomisation uncertainties and sample size requirements for a phase III trial. Click here for further information. CI Dr R Rintoul, Sponsor: Papworth Hospital NHS Foundation Trust
Sleep Disorders
Pulmonary Hypertension
Cystic Fibrosis