Dr Krishnan trained in general and interventional cardiology in Liverpool and Cambridge.

He also undertook basic science research in coronary atherosclerosis during his PhD and academic clinical lectureship attracting funding from the National Institute for Health Research (NIHR), the British Heart Foundation (BHF) and the European Union Sixth Framework Programme for research (EU FP6).

He is very keen on supporting undergraduate and postgraduate medical training in his role as the education lead for the department of Cardiology at Addenbrooke’s Hospital.

 

Specialist Clinical Interests
  • Coronary angioplasty and stenting
  • acute management of unstable coronary disease including heart attacks
  • long term management of stable coronary disease including risk mitigation strategies
  • coordination of multidisciplinary care provision for patients following angioplasty
Research Interests
  • Genetic regulatory factors in coronary artery disease (PhD, University of Leicester & NIHR Academic Clinical Lectureship, University of Cambridge)
Education and Training
  • MBBS: University of Calicut, Kerala, India (Jan 2001)
  • MRCP: Royal College of Physicians, London (Jul 2003)
  • Certification in Cardiology: British Cardiovascular Society (Jun 2011)
  • PhD: University of Leicester (Jul 2013)
  • Cardiac CT accreditation (Level 2): British Society of Cardiac CT (Aug 2016)
  • CCT in Cardiology: (Aug 2016)
  • Postgraduate Certificate in Medical Education: University of Cambridge (Nov 2019)
Current membership(s) of professional, national and regional bodies and university posts
  • Member of the General Medical Council (registration number: 6028800).
  • Member of Royal College of Physicians, London.
  • Member of British Cardiovascular Society.
  • Member of British Cardiovascular Intervention Society.
Recent and Important Publications

Elmahdy W, Osman M, Farag M, Shoaib A, Saad H, Sullivan K, Krishnan U, Nashef S, Berman M. Prosthesis-Patient Mismatch Increases Early and Late Mortality in Low Risk Aortic Valve Replacement. Semin Thorac Cardiovasc Surg. 2021 Spring;33(1):23-30. PMID: 32439547

Valchanov K, Krishnan U, Hoole SP, Davies WR, Pettit S, Jones N, Parmar J, Catarino P, Osman M, Berman M. COVID-19 patient with coronary thrombosis supported with ECMO and Impella 5.0 ventricular assist device: a case report. Eur Heart J Case Rep. 2020 Nov 20;4(6):1-6. PMID: 33442588

Cranley J, Krishnan U, Tweed K, Duehmke RM. Catastrophic antiphospholipid syndrome causing ST-segment elevation myocardial infarction with non-obstructive coronary arteries. BMJ Case Rep. 2019 Jan 10;12(1):bcr-2018-225495. PMID: 30635301

Krishnan U, Karthikeyan VJ, Trinh J, Theologou T, Velavan P. First report of the use of transesophageal echocardiography to position a temporary pacing wire.  J Cardiothorac Vasc Anesth. 2014 Feb;28(1):110-111. PMID: 24011910

Karthikeyan VJ, Krishnan U, Palmer ND. Right coronary artery spasm causing ventricular fibrillation and non-ST elevation myocardial infarction following radial artery cannulation. Heart Asia. 2013 Jun 10;5(1):92-3. PMID: 27326092

Sivapalaratnam S, Basart H, Watkins NA, Maiwald S, Rendon A, Krishnan U, Sondermeijer BM, Creemers EE, Pinto-Sietsma SJ, Hovingh K, Ouwehand WH, Kastelein JJ, Goodall AH, Trip MD.Monocyte gene expression signature of patients with early onset coronary artery disease. PLoS One. 2012;7(2):e32166. PMID: 22363809

Davison LJ, Wallace C, Cooper JD, Cope NF, Wilson NK, Smyth DJ, Howson JM, Saleh N, Al-Jeffery A, Angus KL, Stevens HE, Nutland S, Duley S, Coulson RM, Walker NM, Burren OS, Rice CM, Cambien F, Zeller T, Munzel T, Lackner K, Blakenberg S; Cardiogenics Consortium, Fraser P, Gottgens B, Todd JA, Attwood T, Belz S, Braund P, Cambien F, Cooper J, Crisp-Hihn A, Diemert P, Deloukas P, Foad N, Erdmann J, Goodall AH, Gracey J, Gray E, Williams RG, Heimerl S, Hengstenberg C, Jolley J, Krishnan U, Lloyd-Jones H, Lugauer I, Lundmark P, Maouche S, Moore JS, Muir D, Murray E, Nelson CP, Neudert J, Niblett D, O'Leary K, Ouwehand WH, Pollard H, Rankin A, Rice CM, Sager H, Samani NJ, Sambrook J, Schmitz G, Scholz M, Schroeder L, Schunkert H, Syvannen AC, Tennstedt S, Wallace C. Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene. Hum Mol Genet. 2012 Jan 15;21(2):322-33. PMID: 21989056

Obaji SG, Krishnan U.The masquerade of massive pulmonary embolism. J R Soc Med. 2011 Jan;104(1):35-7. PMID: 21205776

Cooper RM, Krishnan U, Pyatt JR. Central venous spasm during pacemaker insertion. Heart. 2010 Sep;96(18):1484. PMID: 20813728

Abdul-Salam VB, Ramrakha P, Krishnan U, Owen DR, Shalhoub J, Davies AH, Tang TY, Gillard JH, Boyle JJ, Wilkins MR, Edwards RJ. Identification and assessment of plasma lysozyme as a putative biomarker of atherosclerosis. Arterioscler Thromb Vasc Biol. 2010 May;30(5):1027-33. PMID: 20167661

Krishnan U, Win W, Fisher M.​​​​​​​ First report of the successful use of bosentan in refractory vasospastic angina. Cardiology. 2010;116(1):26-8. PMID: 20424449

Krishnan U, Schmitt M. Images in cardiovascular medicine. Persistent thebesian sinusoids presenting as ischemic heart disease.Circulation. 2008 Apr 22;117(16):e315-6. PMID: 18427138

Krishnan U, Goodall AH, Bugert P. Letter in response to ‘myeloid-related protein-14 as a novel determinant of cardiovascular events’. Circulation. 2007 Feb 13;115(6):e186.

Book chapters

Krishnan U, Hoole SP. Coronary angiography. Core Topics in Cardiothoracic Critical Care (2nd Ed). Cambridge University Press. Submitted to Editors 2016.

Krishnan U, Saltissi S. Systolic vs Diastolic dysfunction. Oxford Desk Reference – Geriatric Medicine. Editors: Margot Gosney, Adam Harper and Simon Conroy (First Edition – 12 Jul 2012). ISBN: 978-0-19-959234-0.

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