Jonathan Weir-McCall graduated from the University of Aberdeen in 2002. He entered Radiology training in Guy’s and St. Thomas’, London before moving to the University of Dundee as a Clinical Lecturer. During his training in Dundee he was awarded a Wellcome Trust Clinical Research Fellowship to examine arterial stiffening in chronic obstructive pulmonary artery disease using MRI. After completing his training in Radiology Jonathan undertook a fellowship in Advanced Cardiac Imaging in St Paul’s Hospital under the auspices of Jonathon Leipsic.
During this time he conducted research examining the benefits of cardiac CT in structural and coronary disease, and the potential for computational fluid dynamics to guide and improve the clinical care of coronary artery disease. He was an author on the most recent SCCT guidelines on the use of CTA in the work-up for TAVR, and has worked on several multicentre studies investigating coronary artery disease including SCOT-HEART and ADVANCE.
Jonathan’s interests lie in cardiothoracic imaging, particularly in developing the use of CT and MRI for the assessment of vascular disease in the pulmonary, systemic and coronary territories. The aim of this work is to develop and validate a range of novel biomarkers for disease detection, diagnosis, and measuring response to therapy in order to better select and guide future treatments. He has published over 60 articles in peer reviewed journals, is a regular speaker at national and international conferences, and is on the Editorial board for the Journal of Cardiovascular Computer Tomography and Radiology:Cardiothoracic Imaging.
Specialist Clinical Interests
Cardiac CT and MRI
Atherosclerosis
Arteriosclerosis
Ischaemic heart disease
Structural heart disease
Pulmonary vascular disease.
Undergraduate
2002-2007: University of Aberdeen. Graduated MBChB 2007
Postgraduate
2012: Fellow of the Royal College of Radiologists
2017: Doctorate of Philosophy, University of Dundee
2018: Level III certification in Cardiac CT, SCCT
2019: Level III certification in Cardiac MRI, SCMR
Fellow of the Royal College of Radiologists
Member of the General Medical Council (registration number: 6157467).
Committee member of the Certification and Accreditation Committee, European Association of Cardiovascular Imaging, European Society of Cardiology
Chair-elect, Fellow and Resident Leaders of SCCT (FiRST) committee, Society of Cardiovascular Computed Tomography
Editorial Board member for Journal of Cardiovascular Computer Tomography and Radiology:Cardiothoracic Imaging.
A full list of publications can be found on PubMed.
Attinger-Toller A, Bhindi R, Perlman GY, Murdoch D, Weir-McCall J, Blanke P, Barbanti M, Sathananthan J, Ruile P, Gandolfo C, Saia F, Nietlispach F, Wood D, Leipsic J, Webb JG. Mid-term outcome in patients with bicuspid aortic valve stenosis following transcatheter aortic valve replacement with a current generation device: A multicenter study. Catheter Cardiovasc Interv. 2019 Sep 4. doi: 10.1002/ccd.28475. [Epub ahead of print]
Weir-McCall JR, Wang R, Halankar J, Hsieh J, Hague CJ, Rosenblatt S, Fan Z, Sellers SL, Murphy DT, Blanke P, Xu L, Leipsic JA. Effect of a calcium deblooming algorithm on accuracy of coronary computed tomography angiography. J Cardiovasc Comput Tomogr. 2019 Jul 25.
Pontone G*, Weir-McCall JR*, Baggiano A, Del Torto A, Fusini L, Guglielmo M, Muscogiuri G, Guaricci AI, Andreini D, ADVANCE investigators, Leipsic JA. Determinants of rejection rate for coronary CT angiography fractional flow reserve analysis. Radiology. 2019 Sep;292(3):597-605. *Joint first authorship
McNabney CG, Sellers SL, Wilson RJA, Hart S, Rosenblatt SA, Murphy DT, Blanke P, Ahmadi AA, Halankar J, Attinger-Toller A, Zamorano MG, Yu JWL, Norgaard BJ, Leipsic JA, Weir-McCall JR. Prognosis of Computed Tomography Derived Fractional Flow Reserve (FFRCT) in the Prediction of Clinical Outcomes. Radiology: Cardiothoracic Imaging 2019; In Press
Shaw LJ, Blankstein R, Brown DL, Dhruva SS, Douglas PS, Genders TSS, Gibbons RJ, Greenwood JP, Kwong R, Leipsic J, Mahmarian JJ, Maron D, Nagel E, Nicol E, Nieman K, Pellikka PA, Redberg RF, Weir-McCall J, Williams MC, Chandrasekhar Y. Controversies in Diagnostic Imaging of Patients With Suspected Stable and Acute Chest Pain Syndromes. JACC Cardiovasc Imaging. 2019 Jul;12(7 Pt 1):1254-1278. doi: 10.1016/j.jcmg.2019.05.009.
Holmes KR, Fonte TA, Weir-McCall J, Anastasius M, Blanke P, Payne GW, Ellis J, Murphy DT, Taylor C, Leipsic JA, Sellers SL. Impact of sublingual nitroglycerin dosage on FFRCT assessment and coronary luminal volume-to-myocardial mass ratio. Eur Radiol. 2019 Jun 21. doi: 10.1007/s00330-019-06293-7. [Epub ahead of print]
Nicol ED, Norgaard BL, Blanke P, Ahmadi A, Weir-McCall J, Horvat PM, Han K, Bax JJ, Leipsic J. The Future of Cardiovascular Computed Tomography: Advanced Analytics and Clinical Insights. JACC Cardiovasc Imaging. 2019 Jun;12(6):1058-1072. doi: 10.1016/j.jcmg.2018.11.037.
Williams MC, Moss AJ, Dweck M, Adamson PD, Alam S, Hunter A, Shah ASV, Pawade T, Weir-McCall JR, Roditi G, van Beek EJR, Newby DE, Nicol ED. Coronary Artery Plaque Characteristics Associated With Adverse Outcomes in the SCOT-HEART Study. J Am Coll Cardiol. 2019 Jan 29;73(3):291-301.
Blanke P, Weir-McCall JR, Achenbach S, Delgado V, Hausleiter J, Jilaihawi H, Marwan M, Nørgaard BL, Piazza N, Schoenhagen P, Leipsic JA. Computed Tomography Imaging in the Context of Transcatheter Aortic Valve Implantation (TAVI)/Transcatheter Aortic Valve Replacement (TAVR): An Expert Consensus Document of the Society of Cardiovascular Computed Tomography. Simultaneous co-publication in:
- JACC Cardiovasc Imaging. 2019 Jan;12(1):1-24.
- J Cardiovasc Comput Tomogr. 2018 Dec 11.
Wilson R, McNabney C, Weir-McCall JR, Sellers S, Blanke P, Leipsic JA. Transcatheter Aortic and Mitral Valve Replacements. Radiol Clin North Am. 2019 Jan;57(1):165-178. doi: 10.1016/j.rcl.2018.08.001.
Leipsic J, Weir-McCall J, Blanke P. FFRCT for Complex Coronary Artery Disease Treatment Planning: New Opportunities. Interv Cardiol. 2018 Sep;13(3):126-128. doi: 10.15420/icr.2018.14.3.
Hensey M, Alenezi AR, Murdoch DJ, Sathananthan J, Weir-McCall JR, Wood D, Blanke P, Webb J. Transcatheter Tricuspid Valve-in-Valve Replacement With Subsequent Bioprosthetic Valve Fracture to Optimize Hemodynamic Function. JACC Cardiovasc Interv. 2018 Oct 12. pii: S1936-8798(18)31300-1. doi: 10.1016/j.jcin.2018.06.011.
Weir-McCall JR, Madan N, Villines TC, Shaw LJ, Abbara S, Ferencik M, Nieman K, Blankstein R, Ghoshhajra BB, Choi AD, Nicol E. Highlights of the thirteenth annual scientific meeting of the Society of Cardiovascular Computed Tomography. J Cardiovasc Comput Tomogr. 2018 Oct 1. pii: S1934-5925(18)30311-3.
SCOT-HEART Investigators. Coronary CT Angiography and 5-Year Risk of Myocardial Infarction. N Engl J Med. 2018 Sep 6;379(10):924-933. doi: 10.1056/NEJMoa1805971.
Yu JWL, Omid-Fard N, Arepalli C, Shao M, Hart SL, Weir-McCall J, Rosenblatt SR, Blanke P, Leipsic J. Role of Computed Tomography in Pre-Procedural Planning of Transcatheter Mitral Valve Replacement. Structural Heart 2018;2:23-29.
Sellers SL, Fonte TA, Grover R, Mooney J, Weir-McCall J, Lau KP, Chavda A, McNabney C, Ahmadi A, Blanke P, Payne GW, Murphy DT, Ong K, Taylor CA, Leipsic JA. Hypertrophic Cardiomyopathy (HCM): New insights into Coronary artery remodelling and ischemia from FFRCT. J Cardiovasc Comput Tomogr. 2018 Aug 15. pii: S1934-5925(18)30319-8
Weir-McCall JR, Blanke P, Naoum C, Delgado V, Bax JJ, Leipsic J. Mitral Valve Imaging with CT: Relationship to Transcatheter Mitral Valve Interventions. Radiology 2018 Sep;288(3):638-655.
Weir-McCall JR, Bonnici-Mallia M, Ramkumar PG, Nath AF, Houston JG. Whole-body magnetic resonance angiography. Clin Radiol. 2018 Jul 18. pii: S0009-9260(18)30225-3.
Weir-McCall JR, Liu-Shiu-Cheong PS, Struthers AD, Lipworth BJ, Houston JG. Disconnection of pulmonary and systemic arterial stiffness in COPD. Int J Chron Obstruct Pulmon Dis. 2018 May 28;13:1755-1765
Weir-McCall JR, Blanke P, Sellers SL, Ahmadi AA, Andreini D, Budoff MJ, Cademartiri F, Chinnaiyan K, Choi JH, Chun EJ, Conte E, Gottlieb I, Hadamitzky M, Kim YJ, Lee BK, Lee SE, Maffei E, Marques H, Pontone G, Raff GL, Shin S, Sung JM, Stone P, Samady H, Virmani R, Narula J, Berman DS, Shaw LJ, Bax JJ, Lin FY, Min JK, Chang HJ, Leipsic JA. Impact of Non-obstructive left main disease on the progression of coronary artery disease: A PARADIGM substudy. J Cardiovasc Comput Tomogr. 2018 May - Jun;12(3):231-237.
Lambert M*, Weir-McCall JR*, Salsano M, Gandy SJ, Levin D, Belch JJF, Cavin I, Henderson SA, Littleford R, Macfarlane JA, Matthew SZ, Nicholas RS, Struthers AD, Sullivan F, White RD, Graeme Houston J. Prevalence and distribution of atherosclerosis in a low to intermediate risk population: assessment by whole body MR angiography. Radiology. 2018 Jun;287(3):795-804. *Joint first authorship
Weir-McCall JR, Brown L, Summersgill J, Talarczyk P, Bonnici-Mallia M, Chin SC, Khan F, Struthers AD, Sullivan F, Colhoun HM, Shore AC, Aizawa K, Groop L, Nilsson J, Cockcroft JR, McEniery CM, Wilkinson IB, Ben-Shlomo Y, Houston JG. Development and validation of a pathlength calculation for carotid-femoral pulse wave velocity measurement: A TASCFORCE, SUMMIT and Caerphilly collaborative venture. Hypertension. 2018 May;71(5):937-945.
Weir-McCall JR, Liu-Shiu-Cheong PSK, Struthers AD, Lipworth BJ, Houston JG. Pulmonary arterial stiffening in COPD and its implications for right ventricular remodelling. Eur Radiol. 2018 Aug;28(8):3464-3472.
Al-Talabany S, Mordi I, Graeme Houston J, Colhoun HM, Weir-McCall JR, Matthew SZ, Looker HC, Levin D, Belch JJF, Dove F, Khan F, Lang CC. Epicardial adipose tissue is related to arterial stiffness and inflammation in patients with cardiovascular disease and type 2 diabetes. BMC Cardiovasc Disord. 2018 Feb 13;18(1):31. doi: 10.1186/s12872-018-0770-z.
Weir-McCall JR, Lambert M, Gandy SJ, Belch JJF, Cavin I, Henderson SA, Littleford R, Macfarlane JA, Matthew SZ, Stephen Nicholas R, Struthers AD, Sullivan F, White RD, Graeme Houston J. Systemic arteriosclerosis is associated with left ventricular remodeling but not atherosclerosis: a TASCFORCE study. J Cardiovasc Magn Reson. 2018 Jan 30;20(1):7. doi: 10.1186/s12968-018-0428-0.
Williams MC, Hunter A, Shah ASV, Dreisbach J, Weir McCall JR, Macmillan MT, Kirkbride R, Hawke F, Baird A, Mirsadraee S, van Beek EJR, Newby DE, Roditi G. Impact of noncardiac findings in patients undergoing CT coronary angiography: a substudy of the Scottish computed tomography of the heart (SCOT-HEART) trial. Eur Radiol. 2018 Jun;28(6):2639-2646. doi: 10.1007/s00330-017-5181-5
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